Season 6 (2001)

Episodes
- 1. Richard Lewis
- 2. Vitamin C
- 3. Julia Stiles
- 4. William Dafoe
- 5. Tim Robbins
- 6. Sam Donaldson
- 7. Lynn Whitfield
- 8. Bill O'Reilly
- 9. Matthew McConaughey
- 10. Terry Bradshaw
- 11. Topher Grace
- 12. David Boreanaz
- 13. Dyan Cannon
- 14. James van der Beek
- 15. Tim Blake Nelson
- 16. Dave Grohl
- 17. Kermit the Frog
- 18. Jessica Alba
- 19. Wanda Sykes
- 20. Greg Germann
- 21. Chris Rock
- 22. Kelly Ripa
- 23. Ted Danson
- 24. Joe Pantoliano
- 25. Heather Locklear
- 26. Warren Christopher
- 27. Martin Short
- 28. Ed Burns
- 29. Carmen Electra
- 30. Javier Bardem
- 31. Chris Meloni
- 32. Mary Stuart Masterson
- 33. Jeff Varner
- 34. Denis Leary
- 35. Richard Roeper
- 36. Richard Lewis
- 37. Mark Harmon
- 38. Jennifer Love Hewitt
- 39. Lisa Ling
- 40. Amy Sedaris
- 41. D.L. Hughley
- 42. Steven Weber
- 43. Paul Reubens
- 44. Bob Costas
- 45. Damon Wayans
- 46. Brittany Daniel
- 47. Don Hewitt
- 48. Rachael Leigh Cook
- 49. Tom Green
- 50. Tom Cavanagh
- 51. Eric McCormack
- 52. Dominic Chianese
- 53. No Guest
- 54. Robert Patrick
- 55. Chris Robinson
- 56. James Van Der Beek
- 57. Richie Sambora
- 58. Patricia Richardson
- 59. Maura Tierney
- 60. Denise Quiñones
- 61. Heath Ledger
- 62. Jerry Springer
- 63. Richard Schiff
- 64. Bradley Whitford
- 65. Leah Remini
- 66. Jake Johannsen
- 67. Richard Belzer
- 68. Al Roker
- 69. Bernie Mac
- 70. Joe Queenan
- 71. Gene Simmons
- 72. David Duchovny
- 73. Jeff Greenfield
- 74. Martin Short
- 75. Michael Rapaport
- 76. Alec Baldwin
- 77. Mýa
- 78. Sam Robards
- 79. Johnny Knoxville
- 80. Jet Li
- 81. Bridget Fonda
- 82. Sean Hayes
- 83. The Spice Girls
- 84. James Woods
- 85. Vince Vaughn
- 86. Jon Favreau
- 87. Maria Bartiromo
- 88. Ed Norton
- 89. Hank Azaria
- 90. Larry Miller
- 91. Paul Giametti
- 92. Senator Joe Lieberman
- 93. Senator John McCain
- 94. Jerri Manthey
- 95. Peter Krause
- 96. Jackie Chan
- 97. Janeane Garofalo
- 98. Andie MacDowell
- 99. Joe Rogan
- 100. Tara Reid
- 101. Jason Biggs
- 102. David Rakoff
- 103. John Carpenter
- 104. Seth Green
- 105. Fabio
- 106. Cuba Gooding Jr.
- 107. Griffin Dunne
- 108. Will Ferrell
- 109. Kevin Smith
- 110. They Might Be Giants
- 111. Dave Navarro
- 112. September 20, 2001 - The Comeback episode
- 113. Frank Rich
- 114. Aaron Brown
- 115. Jeff Greenfield
- 116. Tenacious D
- 117. Kelsey Grammer
- 118. Jim Belushi
- 119. Stephen Morse
- 120. Kate Beckinsale
- 121. Owen Wilson
- 122. Jeremy Piven
- 123. John Miller
- 124. Emeril Lagasse
- 125. Lorraine Bracco
- 126. Snoop Dogg
- 127. Fareed Zakaria
- 128. Lance Bass
- 129. Don Dahler
- 130. Greta Van Susteren
- 131. Jeff Bridges
- 132. Rob Morrow
- 133. Richard Holbrooke
- 134. Kevin Spacey
- 135. Paul Rudd
- 136. P.J. O'Rourke
- 137. George Stephanopoulos
- 138. Jennifer Saunders
- 139. Steve Kroft
- 140. Anne Robinson
- 141. Carson Daly
- 142. John Stamos
- 143. Edward Burns
- 144. Star Jones
- 145. Jennifer Garner
- 146. David Halberstam
- 147. Nadine Strossen
- 148. John Edward
- 149. Marg Helgenberger
- 150. Ted Danson
- 151. Stephen Colbert as Al Sharpton
- 152. Dave Gorman
- 153. Janeane Garofalo
- 154. Tracey Ullman
- 155. Elijah Wood
- 156. Peggy Noonan
- 157. Gary Sinise
- 158. Jamie Foxx